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This is somewhat in contrast with the observed dose response for weight and glycemia reductions in the primary results of the trials contributing data, although in the T2D trial in particular there was a convergence of efficacy outcomes across the uppermost doses [25, 26]

Direct head-to-head comparison of tirzepatide vs semaglutide was conducted in the SURPASS-2 trial, which showed tirzepatide 15mg weekly produced significantly greater HbA1c reduction (-2.46% vs -1.86%) and weight loss (-12.4 kg vs -6.2 kg) compared to semaglutide 1mg weekly in type 2 diabetes

However, we also understand that weight loss can be influenced by various factors, including your environment, genetics, and underlying health conditionsmeaning that for some, conventional lifestyle methods arent enough

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In the Seino study, TEAE was the primary outcome measure