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Percentage Weight Loss Expressed as percentage of body weight: Semaglutide (diabetes doses): Average: 4-6% weight loss at 1.0mg dose At 2.0mg dose: 6-8% weight loss At weight-loss doses (Wegovy 2.4mg): ~15% weight loss Dulaglutide: Average: 2-3% weight loss at 1.5mg dose At 4.5mg dose: 3-5% weight loss Weight Loss at Maximum Doses Comparing maximum approved doses: Trulicity 4.5mg: Approximately 4.5 kg (10 lbs) or 3-5% body weight Ozempic 2.0mg: Approximately 6-8 kg (13-18 lbs) or 6-8% body weight Wegovy 2.4mg (semaglutide for weight loss): Approximately 15% body weight For patients prioritizing weight loss, semaglutide offers substantially greater benefit

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Ongoing research endeavors seek to validate their efficacy in managing psychiatric comorbidities