is phentermine a glp-1 receptor agonist Weight-Loss Medication Side Effects and How to Manage Them China: Phentermine–topiramate and GLP-1 receptor

The global prevalence of 537 million affected in the age group of 2079 years in 2021 will rise to 783 million in 2045, with the lowest increase in incidence in Europe (13%) and the highest in the African countries south of the Sahara (134%) (1)

In pediatric patients with genetic obesity, such as those carrying the PNPLA3 p.I148 M variant, bariatric surgery may yield greater liver fat reduction, as observed in a study showing more substantial improvements in liver fat content among PNPLA3-associated steatohepatitis patients compared to non-carriers [207]

These efficacy differences matter when selecting therapy: patients who need maximal weight loss or have struggled to reach glycemic goals on other agents may benefit most from higher efficacy options

The common denominator for treating any of these conditions is a restoration of balanced dopamine levels

Biophys J