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Description
Patients should be counselled about common gastrointestinal symptoms, advised to start with the lowest dose (2.5 mg weekly), and informed that side effects typically improve over 4-8 weeks as tolerance develops

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Additionally, manual scrutiny of reference lists within selected articles was conducted to identify supplementary sources

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The most common side effects were gastrointestinal and two participants experienced more significant adverse events, but were still able to complete the study
