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These hepatic benefits were accompanied by substantial metabolic improvements, including a mean weight loss of 10.5%, better glycaemic control, favourable lipid changes, reduced inflammation and modest reductions in blood pressure

STF-31 in cancer cell lines also targets Glut1, and it has been proposed that STF-31 also exerts an additional inhibitory effect because dual functions are beneficial for inducing cell death in tumors with a high glucose consumption rate

Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic beta-cell mass expansion

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