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2016;311:R124R132

These needles are very small to make the injections as painless as possible

Treatment should only be continued if there is a beneficial metabolic response (reduction of at least 11 mmol/mol [1%] in HbA1c and weight loss of at least 3% of initial body weight at 6 months)
Patients must maintain adequate fluid intake throughout treatment, which can be challenging when appetite and thirst signals are suppressed by medication

So, how are you supposed to mitigate those risks