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However, these tolerability issues ultimately impeded its regulatory and clinical progression

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Epac also acts sensitizing the K ATP channels, but its main function is to facilitate the opening of ryanodine receptor calcium release channels (RYR) on the endoplasmic reticulum, amplifying the intracellular Ca ++ increase (Holz, 2004

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Secreted primarily in the gut in response to food intake, GLP-1 helps slow down stomach emptying, promoting a feeling of fullness and satisfaction after eating

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