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Alimentary Pharmacol Ther (2019) 50:193203

doi: 10.1152/ajplung.1993.265.4.L374 158 GolponHAPuechnerAWelteTWichertPVFeddersenCO

patients in these groups should discuss their suitability with a clinician before participating in any trial Dietary habits high-fat or heavily spiced meals may exacerbate symptoms Diarrhoea in this context is a pharmacological side effect , not an allergic reaction or sign of serious harm in most cases