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[DOI] [PubMed] [Google Scholar] 139.Lahoti S, et al

Deactivation Mechanism of Glucagon-like Peptide-1/2 by Dipeptidyl Peptidase 4 Intestinal L-cells and K-cells release the physiologically active forms of GLP-1 and GIP, known as active GLP-1 amide and GIP, in response to oral glucose via increased cAMP (69)

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The history behind that early trial was simple: in using Wellbutrin in my Internal Medicine practice to treat depressed patients, I found that those same patients were seeing significant weight loss