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ERMCS-localised GLP-1R-dependent PKA signalling requires SPHKAP We next tested the effect of SPHKAP downregulation on GLP-1R-dependent downstream signalling

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These risks in humans are unknown, but retatrutide is contraindicated for individuals with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Tirzepatide produced greater weight loss than semaglutide across all dose comparisons