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Most symptoms are most pronounced during dose escalation phases and tend to diminish within 4-8 weeks of maintaining a stable dose

What baseline labs do you require, and who orders them

These predispositions indicate relative pathway sensitivity but do not predict exact medication response

In response, the hypothalamus may reduce the pulsatile secretion of gonadotropin-releasing hormone (GnRH), which subsequently decreases luteinising hormone (LH) and follicle-stimulating hormone (FSH) production from the pituitary gland

For a broader overview of gastrointestinal and cardiac effects, see our referenced discussion in Side Effects of Wegovy to understand how multiple systems interact