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In this trial, 731 patients with T2DM inadequately controlled on insulin with or without metformin were randomized to oral semaglutide 3, 7 or 14 mg once daily or placebo once daily (1:1:1:1)

However, the most noticeable results typically take a few weeks to become apparent as the body adjusts to the medication

This pattern of fat-to-lean loss appears to reflect general weight loss, rather than something specific to GLP-1 medications

Its limitations must be taken into account when interpreting its results

Males appeared to be at higher risk than females, with the data showing a notably stronger association in male patients taking Wegovy