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In contrast to the CRF-NPY antagonism, central administration of CART activates CRF neurons in the PVN, indicating that CRF may mediate the anorectic effect of CART

This will ultimately work against weight loss efforts and can even negatively affect bone health

Additional support For details about your medication and dosing, please log in to your patient portal

Doses: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg Dosing: Youll start at 0.25 mg once a week and increase gradually over several weeks to reach the maintenance dose that has you losing steady weight, 1 to 2 pounds per week, with the fewest side effects

Szekanecz Z, Buch MH, Charles-Schoeman C, Galloway J, Karpouzas GA, Kristensen LE, Ytterberg SR, Hamar A, Fleischmann R