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Side Effects: Gastrointestinal side effects, such as nausea, are common initially but can be managed by gradually adjusting the dosage

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This reduces the risk of hypoglycaemia compared to some other diabetes treatments, although the risk increases when used with insulin or sulfonylureas

[DOI] [PubMed] [Google Scholar] 25.DeFronzo RA, Reeves WB, Awad AS

However, these studies found no significant improvements in a range of safety endpoints for cardiovascular diseases ( The Role of DPP-4 Inhibitors in Hypertension The first DPP-4 inhibitor, sitagliptin, was approved as an anti-hyperglycemic agent for T2DM in the United States of America in 2006