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Mechanisms of Semaglutide: Slows gastric emptying Reduces appetite Improves satiety Increases insulin secretion Improves blood sugar control Why Semaglutide produces weight loss: The primary mechanism is appetite reduction

Most patients see gradual weight loss over weeks to months, with measurable changes often appearing within 8 to 12 weeks during dose escalation

As this layer diminishes with weight loss, the body loses some of its natural insulation, potentially making individuals more sensitive to ambient temperature changes

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Importantly, these findings were independent of shared cardiometabolic risk factors such as obesity, T2D, hypertension, and dyslipidemia, underscoring the role of sex as an additional modifier of cardiovascular risk in MASLD (250)