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Following the Food and Drug Administrations (FDA) 2008 mandate that new diabetic drugs require a cardiovascular safety assessment, cardiovascular outcome trials (CVOTs) have been conducted to assess all new glucose-lowering pharmacotherapies [8]
Campbell Jonathan E, Drucker DJ

doi: 10.3389/fendo.2022.1033479

The most striking result in the paper may actually be the 44% reduction in all-cause mortality, Yi said

Scientists are currently investigating their potential to slow Alzheimers and Parkinsons disease progression
