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Lessons From Bariatric Surgery: Can Increased GLP-1 Enhance Vascular Repair During Cardiometabolic-Based Chronic Disease

Other peptide additions may enhance semaglutide effects without requiring a complete medication switch

5,12,13 These efforts have yielded six GLP-1 RAsstarting with the development of exendin-4 (Figure 1B)-based exenatide (Figure 1C), followed by liraglutide (Figure 1D), albiglutide, dulaglutide (Figure 1E), lixisenatide, and semaglutide (Figure 1F)that have been approved by the United States Food and Drug Administration (US FDA) to treat type 2 diabetes

In contrast, studies on the currently available oral semaglutide tablets show more modest results

Research on weight loss and body composition consistently demonstrates that higher protein intakes preserve more lean mass during caloric restriction