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these cytokines are produced primarily by adipocytes, tissue-resident macrophages, and infiltrating immune cells (e.g., Th17 cells and other T lymphocytes) within the adipose tissue, which can exacerbate keratinocyte activation and immune dysregulation in psoriatic skin (48)

Excess skin, shifted contours, and tissue that didn't adapt as quickly as the weight came off are common outcomes after major weight loss

Advances in Experimental Medicine and Biology, 1328, 513-522

When inflammation decreases, muscle mass increases, gut health improves, and stress hormones stabilize, GLP-1 and insulin begin working the way they were designed to

Semaglutide is a well-known GLP-1 receptor agonist
