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If the semaglutide-related fatigue lasts longer than expected, there are options to stay on the dose for longer or drop to a lower dose
The role of gastrointestinal vagal afferents in the control of food intake: current prospects

R.ChengI.et al (2020)

It is also used for the prevention of migraine headaches in patients at least 12 years old

The clinical model reflects that distinction