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Orforgliprons approval is the clearest signal yet that metabolic care is shifting toward broad, affordable access
The 2021 STEP 4 trial, published in JAMA, showed that people who continued semaglutide after an initial 20-week run-in kept losing weight, while those who switched to placebo regained nearly 7% of their body weight, confirming that ongoing treatment is key to maintaining results
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Skriver C, Friis S, Knudsen LB, Catarig A-M, Clark AJ, Dehlendorff C, et al
