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It is plausible that retatrutide could offer similar benefits in this group given its potent metabolic effects, but this has not been directly studied
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Furthermore, this novel concept suggests that the GLP-1 analog could spare the pasireotide-induced decrease in endogenous GLP-1 concentrations and recover insulin secretion suppressed by pasireotide through GLP-1R-Gs activation counteracting the SSTRs-Gi axis
