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Description
In a phase 2 study, amycretin showed a mean weight reduction of up to 24.3%, which is comparable to or even greater than the weight loss seen with tirzepatide and similar to the results for retatrutide
Notably, these effects were independent of the extent of weight loss

Bioavailability is lower than injectable semaglutide, which is why the oral doses are much higher
A more expansive study of adult men sought to correlate the subjective reduction in hunger from the first study with anorexigenic biomarkers, specifically GLP-1, CCK and PYY
Due to its significant weight loss effects, tirzepatide has also shown potential in managing conditions like non-alcoholic fatty liver disease (NAFLD), though further research is necessary (43)(46)