glp-1 long term side effects GLP-1RA Essentials in Gastroenterology: Effect Management, Precautions for Endoscopy and Applications for Gastrointestinal Disease Treatment long term side effects of

Blackman et al

Although promising, long-term studies and clinical trials are needed to fully understand GLP-1s impact on the brain

Statements Author contributions The author searched the available literature on the topic using PubMed, Embase, clincal.trials.gov and is the sole independent author of this manuscript and its content

Raised interleukin-6 levels in obese patients

Use in type 1 diabetes The ADJUNCT ONE trial (Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes), 55 the ADJUNCT TWO trial, 56 and a large meta-analysis 57 found reductions in hemoglobin A1c, body weight, and total daily dose of insulin, but also highlighted an increase in hyperglycemia with ketosis in patients with type 1 diabetes mellitus receiving liraglutide or exenatide in combination with insulin