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In 2009, Nauck et al assessed the efficacy and safety of adding liraglutide to metformin compared with placebo or glimepiride to metformin in subjects previously treated with oral antidiabetes (OAD) therapy

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Baseline gut microbiota composition may influence individual responses to GLP-1 receptor agonists and SGLT-2 inhibitors, supporting the potential for microbiota-informed personalized treatment strategies in type 2 diabetes