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Effect of Metformin on Insulin Resistance in Adults with Type 1 Diabetes: A 26-week Randomized Double-blind Clinical Trial

When Dose Reduction Might Be Appropriate If you experience unmanageable side effectssevere nausea, constipation, or vomitingreducing your dose by 0.25 mg while keeping weekly frequency is the medically sound approach, not extending intervals between injections

As Drucker pointed out to me: We know that GLP-1 is not getting directly to those neurons, but it's activating pathways that turn on those neurons
