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Actis Dato V, Lange S, Cho Y

NICE guidelines recommend GLP-1 receptor agonists as add-on therapy for type 2 diabetes when glycaemic targets are not met with other treatments

Endogenous GLP-1 is rapidly cleaved primarily by DPP-4 as well as neutral endopeptidase 24.11 and eliminated by renal clearance, thus resulting in a short half-life of approximately 2 min [26]

Here, we describe the mechanisms by which the two incretins modulate alpha cell secretion of glucagon, review the effects of co-administration of GLP-1 and GIP on glucagon secretion, and discuss the potential role of glucagon in the therapeutic effects observed with novel unimolecular dual GLP-1/GIP receptor agonists

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