pendulum glp 1 alternative Did you know GLP-1 isn't something new—it's something your gut can make on its own. Strains like Akkermansia muciniphila and Clostridium butyricum support your body's natural GLP-1 production by strengthening the gut Pendulum GLP Dynamic GLP1 - GLP-1 Supplement

doi:10.2337/db14-1947 44

DM, diabetes

We therefore conclude that before the place of GLP-1/glucagon co-agonists within the therapeutic armamentarium can be defined, future research efforts need to address the following outstanding questions: What is the optimal balance and receptor potency of GLP-1 and glucagon in a long-acting co-agonist, to minimise adverse effects and to optimise efficacy ( Figure 2 )

In patients with progressive -cell dysfunction, combination therapy is particularly advantageous as it focuses on multiple pathways in glucose regulation and overall increases diabetes control [33]

Companies in this space include mitochondrial uncouplers with enhanced safety profiles (Rivus, Continuum), GDF15 targeting drugs (Novo, Lilly, Janssen), anti- activin II receptor mAb (Versanis), mir-22 inhibition (Resalis Tx) and gut-brain axis modulators (Kallyope)