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In the mesolimbic system, GLP-1R activation has been shown to attenuate the rewarding effects of palatable food and addictive substances, indicating potential therapeutic applications for GLP-1R agonists in treating obesity and SUDs [19,20,21]

A ratio above 0.90 in men or 0.85 in women suggests central obesity and elevated disease risk

Over time, its developers recognized a stronger consumer demand for appetite regulation and metabolic balance

Compared with GLP-1 RAs, more participants receiving tirzepatide 15 mg discontinued treatment due to adverse events (OR 2.29 [95% CI 1.39, 3.75], I 2 0%), whereas no difference was evident for tirzepatide 5 mg and 10 mg (ESM Table 3)

Apps that sync with smart scales or glucose meters can offer real-time feedback to help you stay on course