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These drugs work by increasing insulin release, suppressing glucagon release, and promoting satiety, among other effects

When expanding trial eligibility criteria to reflect broader patient populations typically encountered in clinical practice, we identified 453,201 individuals initiating semaglutide or sitagliptin (expanding SUSTAIN-6 eligibility) and 136,089 initiating tirzepatide or dulaglutide (expanding SURPASS-CVOT eligibility)

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Crossing that line means reduced blood pressure, better blood sugar control, and measurable relief on joints

"Ongoing research hints at benefits for cognitive health, particularly in neurodegenerative diseases like Alzheimer's, as GLP-1 has anti-inflammatory and neuroprotective properties," Dr