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Adding phentermine's stimulant effects and potential appetite loss can escalate nausea to levels where patients cannot eat adequate protein or micronutrients, leading to malnutrition and muscle loss during weight reduction

Obesity is also likely the most significant driver behind increasing cancer rates among younger adults, he says, just as tobacco was in generations past

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In the SELECT trial, it also significantly reduced major adverse cardiovascular events among high-risk patients without diabetes, leading to an indication for cardiovascular risk reduction