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Second, there was considerable heterogeneity in patient demographics (e.g., age), duration of diabetes, medical history (e.g., baseline HbA1c), treatment history, and concomitant medications for T2DM (e.g., insulin, metformin, or other glucose-lowering agents) among the included studies

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[Google Scholar] 74.Hauge C, Breitschaft A, Hartoft-Nielsen M-L, Jensen S, Bkdal TA

Warnings and Safety Considerations 11.1 Risk of Thyroid Tumors Animal studies have demonstrated an increased incidence of thyroid C-cell tumors with GLP-1 receptor agonists

[2] [3] The most frequently documented adverse effects of tirzepatide include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and decreased appetite, which occur in a significant proportion of patients, particularly during dose escalation