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Subgroup analyses were performed to explore efficacy differences in receptor specificity

Despite strong efficacy, systemic barriers like coverage gaps and high out-of-pocket costs, especially for obesity indications, continue to drive abandonment

The mechanistic foundation underlying this therapeutic versatility stems from the widespread distribution of the GLP-1 receptor and its pleiotropic signaling effects, which create a unified framework for understanding clinical benefits across seemingly disparate conditions

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Likewise, they can increase insulin secretion by improving beta-cell survival and suppressing glucagon secretion by improving alpha-cell health and glucose sensing ability