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62 In SURPASS-5, when tirzepatide was added in people who were already on insulin glargine, it led to 2.23% to 2.59% reduction in HbA1c versus 0.93% with placebothis improvement in glycemia was also associated with a reduction in insulin use

Its important to understand that different brands have distinct storage requirements that directly impact how the drugs work. Does semaglutide need to be refrigerated

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Similarly, the question of GLP-1 medications during breastfeeding requires careful consideration of drug timing and clearance

For example, the antidepressant sertraline (Zoloft) affects serotonin production in the brain