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ECM may serve as a reservoir of profibrotic growth factors such as the transforming growth factor (TGF-) and a modulator of their availability and actions
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Advise patients that changes in insulin regimen can predispose to hyperglycemia or hypoglycemia and that changes in insulin regimen should be made under close medical supervision [see Warnings and Precautions (5.2)]

Missed dose: Administer as soon as remembered unless within 24 hours of the next scheduled dose

Wall M, McDermott MP, Kieburtz KD, et al
