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The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

144:1284-1294 [PMC free article: PMC8522627] [PubMed: 34459213] 169

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Chen S., Okahara F., Osaki N., Shimotoyodome A