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Possible safety concerns: While degraded GLP-1 is unlikely to be harmful in itself, it may fail to deliver the expected therapeutic effect, leaving patients unprotected

There is evidence that the use of dipeptidyl peptidase-4 inhibitors (DPP-4) (gliptins) and/or glucagon-like peptide-1 (GLP-1) mimetics is associated with a higher rate of Parkinson's disease compared with the use of other oral antidiabetic drugs 2
