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The mechanism is not fully understood

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Up to -1.65 liter (L) reduction from baseline of 6.81 L in VAT (15 mg) and -2.25 L reduction from baseline of 10.21 L in ASAT (10 mg) compared to an increase with insulin degludec (+0.38 L from 6.34 L baseline and +0.63 L from 10.04 L baseline respectively)

Fluorescently labelled semaglutide is detected in NAcS in alcohol-drinking male and female rats As semaglutide attenuates dopamine release in NAcS by alcohol, the possibility that CY3-semaglutide reaches NAcS after its systemic administration was imaged in alcohol-drinking male and female rats