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Safety issues are as stated above and overall have not been a big concern especially when considering the risk-benefit ratio

Efficacy of conversion of Roux-en-Y gastric bypass to Roux Jejuno-Duodenostomy for severe medically refractory postprandial hypoglycemia

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Thus, ghrelin seems to contribute to the initiation of food intake and to stimulation in motilin-like fashion of gastrointestinal motility

Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2 trial (Lancet Diabetes Endocrinol)