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The glucagon receptor arm the feature that distinguishes retatrutide from earlier-generation incretin compounds drives hepatic glucose metabolism, lipid oxidation, and energy expenditure effects, all absent from GLP-1 mono-agonists and dual GLP-1/GIP agonists

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In addition to stimulating GLP-1 receptors like semaglutide, it also activates GIP, which stands for glucose-dependent insulinotropic polypeptide

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Activation of PKC was analyzed using an antibody that recognizes a PKC-specific phosphorylated sequence in target proteins (Fig

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