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(21) Baseline measurements of P1NP, BMD, and CTX-1 were recorded, and participants were randomized into the semaglutide group to receive 1.0 mg or the placebo group

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Treatment typically begins with a low starting dose , which is gradually increased every 14 weeks (depending on the agent) until the target maintenance dose is reached or the maximum tolerated dose is achieved

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The phase 2 data showed arrhythmias in 4 to 14% of retatrutide groups compared to 2 to 3% in the placebo group

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