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Limited recent data exist on prescribing patterns and patient characteristics for GLP-1 RA medications, whether used as anti-diabetic medication (ADM) for patients with type 2 diabetes (T2D) and/or used as an anti-obesity medication ( for patients with overweight or obesity

[DOI] [PubMed] [Google Scholar] 52.Zander M, Madsbad S, Madsen JL, Holst JJ

For many patients, the 1.7 mg dose delivers meaningful appetite suppression and weight management effects, making dose reduction a viable compromise

Animal testing is the first stage, and human testing is the second stage

It is important to note that although subdiaphragmatic vagal afferent deafferentation in rats inhibits the effects of liraglutide and exendin4 to suppress food intake and body weight at low doses, subdiaphragmatic vagal deafferentation fails to attenuate the food intake and body weight lowering effects of these GLP1 receptor agonists at high doses (Table 3) (Kanoski et al., 2011)