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These molecules cannot directly stimulate T-cells, but they are involved in amplifying the signal derived from the interaction with an antigen via their interaction with other cell surface molecules, thereby leading to T-cell activation ( DPP-4 and Glucose Homeostasis The link between DPP-4 and glucose homeostasis was only identified after the intestinal hormone, glucagon-like peptide-1 (GLP-1) was found to be a DPP-4 substrate

exendin-4 [714,715] and attenuates central GLP-1 effects on brown and inguinal white adipose tissue [666]

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When your immune system detects something it considers harmful, it releases chemicals called cytokines

Acta Physiol (Oxf) (2011) 203(1):25969