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A: Most patients notice reduced appetite within the first week

They reduce de novo lipogenesis by inhibiting transcription factor sterol regulatory element-binding protein 1c (SREBP-1c), which is a master regulator of fatty acid synthesis ( TABLE 1 Therapeutic actions of GLP-1 receptor agonists in liver disease: summary of experimental and clinical findings

Adipose tissue, particularly visceral fat surrounding internal organs, actively produces inflammatory molecules called cytokines

It is also prescribed off-label by healthcare providers for chronic weight management in adults who are obese or overweight with at least one weight-related comorbidity

She points out that obesity, itself, is a severe and chronic disease that carries a high risk for heart disease, strokes, fatty liver disease that could lead to liver cancer, as well as diabetes that can result in kidney disease