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Wegovy contains semaglutide and is approved specifically for weight management in the New Zealand (16), while Mounjaro acts on two hormone pathways (GLP-1 and GIP) and has demonstrated greater average weight loss in head-to-head clinical trials (17)

However, some scholars have proposed that the effect of GLP-1 in the liver is indirectly mediated by multiple mechanisms, such as reducing fat absorption or inhibiting fat cells through acyl-CoA synthetase long chain family member 1 (ACSL1), CCAAT/enhancer binding protein (C/EBP), peroxisome proliferator-activated receptor- (PPAR), and sterol regulatory element binding protein-1c (SREBP-1c) pathways to achieve the purpose of reducing liver lipids [38]

Commonly reported symptoms of menopause include hot flashes, night sweats, vaginal dryness, sleep disturbances, mood swings and weight gain, 1 with an estimated 70% of menopausal women experiencing weight gain

doi: 10.1111/pedi.12730 4 MingesKEWhittemoreRWeinzimerSAIrwinMLRedekerNSGreyM

The acute effects of exendin-4 to reduce food intake and to improve glucose handling are preserved upon knockdown of GLP-1R in the VMH [715], indicating that the effects of central GLP-1R activation on eating and BAT thermogenesis are mediated by at least partially separate brain areas and circuitries