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Notably, the PNP-1-10-0.05 TZP hydrogel group exhibited the most stable HbA1c profiles across animals, highlighting its potential for predictable, long-term glucose regulation

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Conclusion GLP-1 RAs held therapeutic potential for KOA patients with obesity or diabetes, but current evidence remained insufficient, warranting further high-quality RCTs and mechanistic studies to confirm their efficacy and safety

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Any significant weight loss, regardless of method, results in some lean mass loss