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Dowsett GKC, Lam BYH, Tadross JA, Cimino I, Rimmington D, Coll AP, et al

This dual mechanism is why tirzepatide doses start at 2.5 mg while semaglutide starts at 0.25 mg

However, the challenge lies with how the human body biologically defends itself against weight loss

You may not see any visual changes, but the structural damage at the molecular level can reduce potency and increase the risk of injection site reactions