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Additionally, more individuals in the 5, 10, and 15 mg tirzepatide dose groups achieved body weight targets (5%, 10%, and 15% weight loss from baseline) than those in the dulaglutide group

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have antihyperglycemic and pleiotropic effects that reduce cardiovascular mortality in individuals with T2DM [6]

Our recent results indicate that AMPK and S6K1 are functionally expressed in the VMH and LH areas, with differential activation in response to glucose fluctuations, in both in vitro models of hypothalamic organotypic slice cultures and animals in response to fasting and re-feeding, as well as in Zucker obese rats with a lower activation degree of hypothalamic AMPK in response to fasting