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The TRIUMPH program enrolled more than 5,800 participants across multiple registrational trials evaluating retatrutide across obesity, obstructive sleep apnoea, and knee osteoarthritis comorbidities

A.OkersonT.ViswanathanP.GuanX.HolcombeJ

About this article Cite this article Kuran, ., Kkkasap, T

Intriguingly, one of these studies also showed that longer administrations can lead to a normalization of anxiety and a dissociable improvement in depression-like behavior 158 a pattern that resembles of the mechanisms of action of conventional antidepressants and that may be further suggestive of the activity of GLP-1RAs on the serotonin system 158

Multiple reviewers were surprised by this, expecting a flat rate throughout treatment
