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Semaglutide appears to be overall safe for over two years of continuous use according to recent research findings reported by JAMA Internal Medicine journal

Using familiar clinical markers and intervening earlier is a much more modern, proactive model of care, she says

Rubino D., Abrahamsson N., Davies M., et al., Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial, Journal of the American Medical Association 325 (2021): 14141425

The result is a peptide that survives long enough after injection to produce meaningful, sustained effects on growth hormone secretion

Sep 2011;100(9):3594-601