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Results Despite heterogeneity in study designs and populations, a largely consistent association was found between GLP-1RA use and a reduced incidence of glaucoma

Genetic instruments were derived from cis-eQTLs for GLP-1R, and analyses were conducted using large-scale GWAS datasets

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In rare reports this can have serious or fatal outcomes * seek urgent medical attention if you experience severe, persistent abdominal pain, that may radiate to your back and may be accompanied by nausea and vomiting, as this may be a sign of pancreatitis * do not restart GLP-1 receptor agonist or GLP-1/GIP receptor agonist treatment if pancreatitis is confirmed * report suspected side effects through the Yellow Card scheme.

Semaglutide works in the same way as a hormone produced in the gut by increasing the amount of insulin that the pancreas releases in response to food.